The liver is the largest solid organ in the human body and it has about 500 different tasks, according to Medical News Today. For instance, the liver detoxifies the blood, it creates proteins that prevent blood clotting, and more.
Various medical conditions can affect the liver, one of which is fatty liver disease. One study looked at the disease and determined that those with the condition also exhibit a great deal of fatigue. The study, titled Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability, apparently had adolescents as participants. Researchers collected information on weight-adjusted physical work capacity, and various other indicators, from 390 female and 458 male participants.
The study concluded that in “a well-defined cohort of adolescents” non-alcoholic fatty liver disease was associated with a decrease in cardiorespiratory fitness, independent of body mass index.
The reasoning for the increase in fatigue could be due to the condition’s impairment of the body’s ability to provide the blood with an adequate amount of iron. Thus, those with the condition essentially experience an iron deficiency, which then leads to fatigue.